Increased FNDC5 (irisin) expression in subcutaneous adipose tissue in obese patients with type 2 diabetes 1 year after bariatric surgery
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چکیده
منابع مشابه
Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue
BACKGROUND Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression reflect a restoration of a healthy lean phenotype after bariatric surgery. METHODS Thirty-one s...
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Objective(s): Visfatin and vaspin are secreted by adipose tissue and play key roles in glucose homeostasis and subsequently are potential targets for diabetes treatment. Resveratrol (RVS) corrects insulin secretion and improves insulin sensitivity. We investigated the RVS effects on serum antioxidants, insulin and glucose levels, also visfatin and vaspin genes expression in adipose tissue of st...
متن کاملMetallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients.
STUDY BACKGROUND Insulin resistance plays an important role in the pathogenesis of type 2 diabetes and the metabolic syndrome. Many of the genes and pathways involved have been identified but some remain to be defined. Metallothioneins (Mts) are a family of anti-oxidant proteins and metallothionein 2a (Mt2a) polymorphims have been recently associated with type 2 diabetes and related complicatio...
متن کاملTHE EFFECT OF EIGHT WEEKS OF HIGH INTENSITY INTERVAL TRAINING ON CREB AND CRTC2 PROTEINS LEVELS IN SUBCUTANEOUS ADIPOSE TISSUE OF OBESE RATS WITH TYPE 2 DIABETES
Background: Obesity and type 2 diabetes can impair the function of cells, including CREB and CRTC2 proteins, which are important for regulating adipose tissue metabolism. Therefore, the purpose of the present study was to investigate the effect of eight weeks of high intensity interval training (HIIT) on CREB and CRTC2 proteins levels in subcutaneous adipose tissue of obese rats with type 2 dia...
متن کاملMetabolic outcomes 1 year after gastric bypass surgery in obese people with type 2 diabetes.
OBJECTIVE To assess metabolic outcomes in obese people with type 2 diabetes (T2D) in the first year following gastric bypass surgery. SUBJECTS AND METHODS Forty-nine obese patients with T2D who had undergone gastric bypass surgery 12 or more months previously were identified. Body weight and glycosylated haemoglobin (HbA(1c)) pre-operatively and 3, 6 and 12 months postoperatively, changes to ...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2015
ISSN: 1479-6848
DOI: 10.1530/endoabs.37.ep622